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Importantly, a clinical study has demonstrated that combining radiotherapy with higher doses of the TGF-blocking antibody fresolimumab (10 mg/kg) increases overall survival significantly in metastatic breast cancer patients compared to those undergoing radiotherapy and receiving lower doses of fresolimumab (1 mg/kg) [135]

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doi:10.1016/j.nut.2015.12.039 , 3 Hijlkema A, Roozenboom C, Mensink M, Zwerver J